Recent Publications

The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes
Simon Ullrich, Susanne Leidescher, Yana Feodorova, Katharina Thanisch, Jean-Baptiste Fini, Bernd Kaspers, Frank Weber, Boyka Markova, Dagmar Fuehrer, Mirian Romitti, Stefan Krebs, Helmut Blum, Heinrich Leonhardt, Sabine Costagliola, Heike Heuer, Irina Solovei Front. Cell Dev. Biol. 11, 1265407 (2023).

Mesodermal FGF and BMP govern the sequential stages of zebrafish thyroid specification
Benoit Haerlingen, Robert Opitz, Isabelle Vandernoot, Angelo Molinaro, Meghna Parakkal Shankar, Pierre Gillotay, Achim Trubiroha, Sabine Costagliola; Development 2023; dev.201023. doi: https://doi.org/10.1242/dev.201023

Single-cell transcriptomics uncovers the differentiation of a subset of murine esophageal progenitors into taste buds in vivo
Vercauteren Drubbel A, Beck B. Sci Adv. 2023 Mar 10;9(10):eadd9135. doi: 10.1126/sciadv.add9135. Epub 2023 Mar 8. PMID: 36888721; PMCID: PMC9995038.

Zebrafish Galectin 3 binding protein is the target antigen of the microglial 4C4 monoclonal antibody
Rovira M, Miserocchi M, Montanari A, Hammou L, Chomette L, Pozo J, Imbault V, Bisteau X, Wittamer V. Dev Dyn. 2023 Mar;252(3):400-414. https://doi.org/10.1002/dvdy.549

Dynamic Cancer Cell Heterogeneity: Diagnostic and Therapeutic Implications
Cancers 14 (2) 280.Jacquemin V., Antoine M., Dom G., Detours V., Maenhaut C., Dumont J.E. (2022)

Microglia states and nomenclature: A field at its crossroads
Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Brône B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK, Gokce O, Gomez-Nicola D, González B, Gordon S, Graeber MB, Greenhalgh AD, Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A, Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE, Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H, Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M, Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons M, Smith CJ, Streit WJ, Tay TL, Tsai LH, Verkhratsky A, von Bernhardi R, Wake H, Wittamer V, Wolf SA, Wu LJ, Wyss-Coray T. Neuron. 2022 Nov 2;110(21):3458-3483. https://doi.org/10.1016/j.neuron.2022.10.020

Emerging Technologies in Thyroid Biology: Pushing the Frontiers of Thyroid Research
Costagliola, S., Singh, S. Molecular and Cellular Endocrinology, https://doi.org/10.1016/j.mce.2023.111912

Thyroid-on-a-chip: An Organoid Platform For In Vitro Assessment of Endocrine Disruption
Carvalho, D. J., Kip, A. M., Romitti, M., Nazzari, M., Tegel, A., Stich, M., Krause, C., Caiment, F., Costagliola, S., Moroni, L., Giselbrecht, S., Adv. Healthcare Mater. 2022, 2201555. https://doi.org/10.1002/adhm.202201555

Loss-of-function N178T variant of the human P2Y4 receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis
Michael Horckmans, Esteban Diaz Villamil, Céline Verdier, Henrik Laurell, H., Jean-Bernard Ruidavets, Lucas De Roeck, Guillaume Combes, Laurent O. Martinez and Didier Communi. Frontiers in Pharmacology (2022) https://doi.org/10.3389/fphar.2022.1049696

Central role of PD-L1 in cardioprotection resulting from P2Y4 nucleotide receptor loss
Michael Horckmans, Esteban Diaz Villamil, Mariaelvy Bianchini, Lucas De Roeck and Didier Communi. Frontiers in Immunology (2022). https://doi.org/10.3389/fimmu.2022.1006934

UTP regulates the cardioprotective action of transplanted stem cells derived from mouse cardiac adipose tissue
Esteban Diaz Villamil, Lucas De Roeck, Marion Vanorlé and Didier Communi. Frontiers in Pharmacology (2022) https://doi.org/10.3389/fphar.2022.906173

Regionally specific levels and patterns of keratin 8 expression in the mouse embryo visceral endoderm emerge upon anterior-posterior axis determination
Evangéline Despin-Guitard, Ronan Quenec’Hdu, Wallis Nahaboo, Nicole Schwarz, Rudolf E.Leube, Claire Chazaud and Isabelle Migeotte. Frontiers in Cell and Developmental Biology (2022) https://doi.org/10.3389/fcell.2022.1037041

Cerebrospinal Fluid Proteomics in Friedreich Ataxia Reveals Markers of Neurodegeneration and Neuroinflammation.
Frontiers in Neuroscience, 16, 885313. https://doi:10.3389/ fnins.2022.885313. Imbault, V., Dionisi, C., Naeije, G., Communi, D., & Pandolfo, M. (2022).

Danger-associated Molecular Patterns After Traumatic and Nontraumatic Acute Brain Injury: A Prospective Study.
Journal of neurosurgical anesthesiology. https://doi:10.1097/ANA.0000000000000916. Santacruz, C. A., Vincent, J. L., Duitama, J., Bautista, E., Imbault, V., Bruneau, M., Creteur, J., Brimioulle, S., Communi, D., & Taccone, F. (2023). vCSF

Proprioceptors-enriched neuronal cultures from induced pluripotent stem cells from Friedreich ataxia patients show altered transcriptomic and proteomic profiles, abnormal neurite extension.
Brain Communications, 5(1), fcad007. https://doi:10.1093/braincomms/fcad007. Dionisi, C., Chazalon, M., Rai, M., Keime, C., Imbault, V., Communi, D., Puccio, H., Schiffmann, S. N., & Pandolfo, M. (2023).

Association of cerebrospinal fluid protein biomarkers with outcomes in patients with traumatic and non-traumatic acute brain injury: systematic review of the literature.
Critical care, 25(1), 278. https://doi:10.1186/s13054-021-03698-z. Santacruz, C. A., Vincent, J. L., Bader, A., Rincón-Gutiérrez, L. L., Dominguez-Curell, C., Communi, D., & Taccone, F. (2021).

Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism
Mírian Romitti, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Adrien Tourneur, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff, Sabine Costagliola Nat Commun 13, 7057 (2022). https://doi.org/10.1038/s41467-022-34776-7, https://doi.org/10.1038/s41467-022-34776-7

Loss of tetraspanin-7 expression reduces pancreatic beta-cell exocytosis Ca2+ sensitivity but has limited effect on systemic metabolism
Kerry McLaughlin, Samuel Acreman, Sameena Nawaz, Joseph Cutteridge, Anne Clark, Jakob G. Knudsen, Geoffrey Denwood, Aliya F. Spigelman, Jocelyn E. Manning Fox, Sumeet Pal Singh, Patrick E. MacDonald, Benoit Hastoy, Quan Zhang, Diabetic Medicine, 20 October 2022, https://doi.org/10.1111/dme.14984

Murine Thyroid IL-4 Expression Worsens Hypothyroidism on Iodine Restriction and Mitigates Graves Disease Development
Merakchi K, Djerbib S, Soleimani M, Dumont JE, Miot F, De Deken X. Endocrinology. 2022 Sep 1;163(9):bqac107. doi: 10.1210/endocr/bqac107.PMID: 35881515

Cellular senescence modulates progenitor cell expansion during axolotl limb regeneration
Qinghao Yu, Hannah E. Walters, Giovanni Pasquini, Sumeet Pal Singh, Daniel León-Periñán, Andreas Petzold, Preethi Kesavan, Cristina Subiran, Ines Garteizgogeascoa, Dunja Knapp, Anne Wagner, Andrea Bernardos, María Alfonso, Gayathri Nadar, Andreas Dahl, Volker Busskamp, Ramón Martínez-Máñez, Maximina H. Yun. bioRxiv, 2022.09.01.506196; https://doi.org/10.1101/2022.09.01.506196