Recent Publications
In vivo imaging of calcium dynamics in zebrafish hepatocytes
Pozo-Morales, M., Garteizgogeascoa, I., Perazzolo, C., So, J., Shin, D. and Singh, S.P. (2022), . Hepatology. Accepted Author Manuscript. https://doi.org/10.1002/hep.32663
Zebrafish Galectin 3 binding protein (Lgals3bp) is the target antigen of the microglial 4C4 monoclonal antibody
Mireia Rovira, Alice Montanari, Latifa Hammou, Laura Chomette, Magali Miserocchi, Jennifer Pozo, Virginie Imbault, Xavier Bisteau, Valérie Wittamer https://doi.org/10.1101/2022.04.05.486973
Foxe1 orchestrates thyroid and lung cell lineage divergence in mouse stem cell-derived organoids
Fonseca B F, Barbee C, Romitti M, Eski S E, Gillotay P, Monteyne D, Perez-Morga D, Refetoff S, Singh S P and Costagliola S 2022 bioRxiv 2022.05.16.492074. https://doi.org/doi:10.1101/2022.05.16.492074.
An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4
Audrey G. Reeves, Angel Gonzalez-Valero, Patrick J. Moon, Edward Miller, Katia Coulonval, Steven W. M. Crossley, Xiao Xie, Dan He, Patricia Z. Musacchio, Alec H. Christian, Jeffrey M. McKenna, Richard A. Lewis, Eric Fang, Dustin Dovala, Yipin Lu, Lynn M. McGregor, Markus Schirle, John A. Tallarico, Pierre P. Roger, F. Dean Toste, and Christopher J. Chang. ChemRxiv (April 2022) https//doi.org/10.26434/chemrxiv-2022-9p94z
Monoclonal antibodies to activated CDK4: Use to investigate normal and cancerous cell cycle regulation and involvement of phosphorylations of p21 and p27
Coulonval, K., Vercruysse, V., Paternot, S., Pita, J.M., Corman, R., Raspé, E., Roger, P.P. Cell Cycle, 21(1) :12-32 (jan. 2022)
Preclinical evaluation of CDK4 phosphorylation predicts high sensitivity of malignant pleural mesotheliomas to CDK4/6 inhibition
Paternot S, Raspé E, Meiller C, Tarabichi M, Assié JB, Libert F, Remmelink M, Bisteau X, Pauwels P, Blum Y, Le Stang N, Tabone-Eglinger S, Galateau-Salle F, Blanquart C, Van Meerbeeck JP, Berghmans T, Jean D, Roger PP. bioRxiv (april 2022) doi: https://doi.org/10.1101/2022.04.11.487857
The Atypical Chemerin Receptor GPR1 Displays Different Modes of Interaction with β-arrestins in Humans and Mice with Important Consequences on Subcellular Localization and Trafficking
Degroot, G-N, Lepage, V., Parmentier M. and Springael, J-Y (2022) Cells in press.
Signal Transduction by VIP and PACAP Receptors
I. Langer, J. Jeandriens, A. Couvineau, S. Sanmukh, D. Latek. Biomedicines (2022) 9;10(2):406. doi: 10.3390/biomedicines10020406.
Cold Atmospheric Plasma Differentially Affects Cell Renewal and Differentiation of Stem Cells and Apc-Deficient-Derived Tumor Cells in Intestinal Organoids.
A. Hadefi, M. Leprovots, M. Thulliez, O. Bastin, A. Lefort, F. Libert, A. Nonclercq, A. Delchambre, F. Reniers, J. Deviere, MI Garcia. Cell Death Discovery (2022) 8:66 ; https://doi.org/10.1038/s41420-022-00835-7.
Keratin filaments mediate the expansion of extra-embryonic membranes in the post-gastrulation mouse embryo
Wallis Nahaboo, Sema Elif Eski, Evangéline Despin-Guitard, Marjorie Vermeersch, Marie Versaevel, Bechara Saykali, Daniel Monteyne, Sylvain Gabriele, Thomas M Magin, Nicole Schwarz, Rudolf E Leube, An Zwijsen, David Perez-Morga, Sumeet Pal Singh, Isabelle Migeotte. The EMBO Journal (2022) e108747.https://doi.org/10.15252/embj.2021108747
Nrf2 promotes thyroid development and hormone synthesis
Pierre Gillotay, Mirian Romitti, Benjamin Dassy, Benoit Haerlingen, Meghna Parakkal Shankar, Barbara De Faria Da Fonseca, Panos G. Ziros, Sumeet Pal Singh, Gerasimos Sykiotis, Sabine Costagliola. bioRxiv 2022.02.27.482168; doi: https://doi.org/10.1101/2022.02.27.482168
A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ cells to diabetes recovery in zebrafish
Sumeet Pal Singh, Prateek Chawla, Alisa Hnatiuk, Margrit Kamel, Luis F Delgadillo Silva, Bastiaan Spanjaard, Sema Elif Eski, Sharan Janjuha, Pedro Olivares Chauvet, Oezge Kayisoglu, Fabian Rost, Juliane Blasche, Annekathrin Krankel, Andreas Petzold, Thomas Kurth, Susanne Reinhardt, Jan Philipp Junker, Nikolay Ninov., Development (2022) 149 (2): dev199853. https://doi.org/10.1242/dev.199853
Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
Guilliams M, Bonnardel J, Haest B, Vanderborght B, Wagner C, Remmerie A, Bujko A, Martens L, Thoné T, Browaeys R, De Ponti FF, Vanneste B, Zwicker C, Svedberg FR, Vanhalewyn T, Gonçalves A, Lippens S, Devriendt B, Cox E, Ferrero G, Wittamer V , Willaert A, Kaptein SJF, Neyts J, Dallmeier K, Geldhof P, Casaert S, Deplancke B, Ten Dijke P, Hoorens A, Vanlander A, Berrevoet F, Van Nieuwenhove Y, Saeys Y, Saelens W, Van Vlierberghe H, Devisscher L, Scott CL. Cell. 2022 Jan 5:S0092-8674(21)01481-1. doi: 10.1016/j.cell.2021.12.018.
Repositioning For Allosteric Modulation of VIP and PACAP Receptors
Langer I, Latek D. Drug . Front Endocrinol (Lausanne). 2021 Nov 18;12:711906. doi: 10.3389/fendo.2021.711906. eCollection 2021.
Involvement of chemerin and CMKLR1 in the progesterone decrease by PCOS granulosa cells
Estienne A, Mellouk N, Bongrani A, Plotton I, Langer I, Ramé C, Petit C, Guérif F, Froment P, Dupont J. Reproduction. 2021 Oct 28;162(6):427-436. doi: 10.1530/REP-21-0265.
Transcriptomic signature of human embryonic thyroid reveals transition from differentiation to functional maturation
Dom G., Dmitriev P., Lambot MA., Van Vliet G., Glinoer D., Libert F., Lefort A., Dumont J.E., Maenhaut C. (2021) . Frontiers in Cell and Developmental Biology 9,
MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways
Augenlicht A., Saiselet M., Decaussin-Petrucci M., Andry G., Dumont J.E., Maenhaut C. (2021) Oncotarget 12, 1587-1599.
Single-cell trajectory inference guided enhancement of thyroid maturation in vitro using TGF-beta inhibition
M. Romitti, S. E. Eski, B. F. Fonseca, P. Gillotay, S. P. Singh, and S. Costagliola, Front Endocrinol12, 657195 (2021).
Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia
Vercauteren Drubbel A, Pirard S, Kin S, Dassy B, Lefort A, Libert F, Nomura S, Beck B. Cell Stem Cell. 2021 Apr 14:S1934-5909(21)00152-1. doi: 10.1016/j.stem.2021.03.019. Epub ahead of print. PMID: 33882290.
In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration
M. I. Pronobis, S. Zheng, S. P. Singh, and K. D. Poss, bioRxiv, p. 2021.01.19.427246, Jan. 2021.