In this study, Gayathri Vilangappurath, Özüm Begüm Böke, and Anchel de Jaime-Soguero present robust and reproducible protocols for directing human pluripotent stem cells toward early embryonic lineages, alongside methods to evaluate their genomic and chromosomal integrity. By combining efficient differentiation strategies with tools to monitor DNA damage and chromosomal instability, this work provides valuable resources for studying early human development and improving the reliability of stem cell-based research, with important implications for disease modeling and regenerative medicine.
Read this publication: https://pubmed.ncbi.nlm.nih.gov/42921815/
