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https://www.iribhm.org/research-labs/ade-jaime-soguero monthly 0.5 2025-04-25 https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/ce1cbc86-ae9d-4543-b341-4fa63d676ef7/Image1-1.png Research Labs - A.De Jaime Soguero - Make it stand out De Jaime-Soguero, et al. Nature Communications (2024) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/371f6632-5e26-414c-8b3e-baed4e496f65/Capture-2.png Research Labs - A.De Jaime Soguero https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/6daed243-72d0-46eb-9661-7caa654d1f9b/Image3-1.jpg Research Labs - A.De Jaime Soguero - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/02528fc3-d06a-4fe3-a3a2-8b47d569d64e/Image4.jpg Research Labs - A.De Jaime Soguero - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/ce82e8e8-4488-4a96-9c51-e81d8a39c06a/Image5-1.jpg Research Labs - A.De Jaime Soguero - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/026074bf-266c-4fa0-852b-bb06a933d572/2025042229566198.jpg Research Labs - A.De Jaime Soguero - Anchel de Jaime Soguero – Junior group leader (anchel.de.jaime.soguero@ulb.be) I received my PhD from KU Leuven (Belgium), where I studied the transcriptional regulation of Wnt signaling. In 2019, I moved to the University of Heidelberg under the guidance of Prof. Sergio Acebron where I unveiled how morphogenetic signals regulate genome integrity and chromosome stability. Since October 2024, I lead my group at IRIBHM dissecting cellular stress responses across lineage states and mammalian embryo development. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/2c7f779a-399e-4b4e-8590-7cd72bd924b7/iribhm-logo.png Research Labs - A.De Jaime Soguero https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1740573249325-DW7WCA1PVZTD5ZITP298/Image8.png Research Labs - A.De Jaime Soguero https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1740573212370-UKFK7VCH87FKSU8WG2V7/Image9.png Research Labs - A.De Jaime Soguero https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1740573198842-1Y0GD3G7UB7QYPTOVHLA/Image2-2.png Research Labs - A.De Jaime Soguero https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1740573201018-EAW7869QOGI9SWN5K99G/Image10.png Research Labs - A.De Jaime Soguero https://www.iribhm.org/research-labs/b-beck monthly 0.5 2026-02-06 https://www.iribhm.org/research-labs/c-maenhaut monthly 0.5 2026-02-06 https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1f7f6c21-18c7-4c20-a69b-f2911bbfc455/Image1-3-768x439.png Research Labs - C. Maenhaut - Make it stand out Figure: Thyroid tumorigenesis, altered signaling pathways and main mutations https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/d203705d-c550-4770-8ee1-64e53dedf58f/Carine+Maenhaut+%281%29.jpg Research Labs - C. Maenhaut - Carine Maenhaut, PI Carine.Maenhaut@ulb.be Phone # +32 (0)2 555 4137 https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/3ed70e61-7603-4dd4-94b1-cbc308cc34a1/Nicolas+Henry.jpg Research Labs - C. Maenhaut - Nicolas Henry https://www.iribhm.org/research-labs/david-communi monthly 0.5 2025-07-10 https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/862d0114-fc57-447b-982b-73af72c4cad4/David-Pic.jpg Research Labs - David Communi - Make it stand out SWATH analysis, from AB Sciex https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/c4243703-14a6-4d0b-805e-2384fbcd8e23/2025042233301990.jpg Research Labs - David Communi - David Communi PhD, Principal Investigator, Senior Research Associate FNRS (dcommuni@ulb.ac.be) phone # +32 (0)2 555 4150 https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/7d79b949-5176-4232-974a-7a5f7db8e6fd/Virginie+Imbault.jpg Research Labs - David Communi - Virginie Imbault Platform technical manager (biomolecule purification and quantitative proteomics) https://www.iribhm.org/research-labs/didier-communi monthly 0.5 2025-07-10 https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/b1ae4cc1-44e2-4fc6-a45a-f788d3aa8b8b/Infarct-624x155.jpg Research Labs - Didier Communi - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/9eec1fc1-2016-446b-855c-1105b02ebf85/Fibrosis-300x225.jpg Research Labs - Didier Communi - The starting point of our projects is the analysis of the cardiac phenotype of mice deficient for extracellular nucleotide receptors and cardioprotective adipokines. We acquired previously an expertise in the field of extracellular nucleotides and pharmacology of GPCRs by the cloning and the study of human P2Y nucleotide receptors. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/621bac84-38b4-4a2f-a4ec-b28e248345cc/zoom-falcs-e1524474679940-300x263.jpg Research Labs - Didier Communi - Recently fat-associated lymphoid clusters (FALCs) have been identified in adipose tissues as areas containing innate-like B and T cell populations. The formation of these clusters can be induced by inflammation and ischemia, and associated to rapid immune responses. The exact composition, distribution, function of FALCs remain unknown. Interestingly we observed that P2Y nucleotide receptors are involved in protection against myocardial infarction, in formation of heart, cardiac fat and FALCs, and finally in secretion of cardioprotective adipokines. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/65c6e464-ef9f-4fd6-bf10-cb41af74f7ed/FNRS-624x395.jpg Research Labs - Didier Communi - Role of nucleotide receptors in the cardioprotective properties of cardiac adipose tissue-derived stem cells and in the regulation of anti-inflammatory exosomes after myocardial infarction FNRS https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/7c81d06b-2341-4214-8fcd-32cd07652167/Screenshot+2025-03-04+at+14.07.30.png Research Labs - Didier Communi - Role of adiponectin and PD-L1 in the release of cardioprotective exosomes BHF 2023 prize, Basic Research in Cardiology grant, Belgian Heart Foundation, Fondation Roi Baudouin https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/5b746679-23c6-4b99-aa34-1a58082ddc59/Fonds-pour-la-Chirurgie-Cardiaque-logo.jpg Research Labs - Didier Communi - Characterization of anti-inflammatory exosomes involved in cardioprotection resulting from loss of P2Y4 nucleotide receptor Fonds pour la Chirurgie Cardiaque https://www.iribhm.org/research-labs/f-willermain monthly 0.5 2025-07-10 https://www.iribhm.org/research-labs/ghopat-23kc9-4mcby monthly 0.5 2026-02-06 https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773217397-57DGRTOF1EP5BIEMCZJW/Image1.jpg Research Labs - I. Langer https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773217180-2I43APEYN88F86FOXS13/Image2.jpg Research Labs - I. Langer https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773218494-UH4VQDCIAE8VYCHQNV1N/Image3.jpg Research Labs - I. Langer https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773218927-T9QP5SJ34PZZ6KQOZPE3/Image4.jpg Research Labs - I. Langer https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773219982-FYT2S4D6RUTKENP3W4NV/Image5.jpg Research Labs - I. Langer https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773220989-DZ2BR8K2JE01FMUOX6ZJ/Page+garde+1+-springael.jpg Research Labs - I. Langer https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773222312-UXNG8657DWMWV9WAS284/Page+garde+2+springael.jpg Research Labs - I. Langer https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/2cfefeda-50e3-4bb5-9772-47c5ef0108ba/isa-1.jpg Research Labs - I. Langer - Marie-Isabelle Garcia Lab Intestinal stem cell biology https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/8d05e5bd-ecba-411a-b60f-6e59befe44a1/ingrid-2.jpg Research Labs - I. Langer - Ingrid LANGER Lab Structure and function of VIP receptors in physiological and pathological conditions https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/b350cd65-0b0c-4851-a29a-8318676af7eb/jy-2.gif Research Labs - I. Langer - Jean-Yves SPRINGAEL Lab Chemokine Receptors in Physiology and Pathology https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/756f3ed4-fdfc-4c36-a5db-51ce3f02d42a/2025042247449978.jpg Research Labs - I. Langer - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/f4d84347-48b4-47d4-901e-aa520561ac65/Marie-Isabelle+Garcia.jpg Research Labs - I. Langer - Marie-Isabelle Garcia, PhD PhD in Biochemistry (University Paris 7, FR) Professor of biochemistry at the Faculty of Medicine (ULB) Email : Marie.Garcia@ulb.be https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/669c3b65-78a1-4744-b851-3403e6f75287/Image15.jpg Research Labs - I. Langer - Ingrid Langer PharmD, PhD PhD in Pharmaceutical Sciences (ULB, BE) Professor of pharmacology at the Faculty of Medicine (ULB) Email : Ingrid.Langer@ulb.be https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/2e4f42ad-8271-40d4-9ce8-0d28008aa3dd/2025042246850714.jpg Research Labs - I. Langer - Jean-Yves Springael, PhD PhD in Chemical Sciences (ULB, BE) Professor of biochemistry at the Faculty of Medicine (ULB) Email : Jean-Yves.Springael@ulb.be https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/244b5895-2b84-4127-9089-7997f347998b/Morgane+Leprovots.jpg Research Labs - I. Langer - Morgane LEPROVOTS BA in Cellular biology, genetics, microbiology and physiology (University of Rennes -FR), vocational BA in biology (IUT Tours -FR) MA degree in life sciences and earth from the EPHE (FR) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/7f9f4d62-a5db-4a80-a253-d7a6ff18cf5c/Image18-1-2.jpg Research Labs - I. Langer - Giulia AGOSTINI MA in BIiomolecular, genomic and cellular Sciences (University of Parma, IT) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/87ac5284-8a45-412b-be36-aba499529446/original-4115DD5A-30BD-4CAB-B135-9D82CBF10159-624x907.jpg Research Labs - I. Langer - Lilian DEMOLIN, MD MD Medical sciences (ULB) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1ed8b055-8f91-4bb6-ba0a-300a32e7c5a8/J%C3%A9r%C3%B4me+Jeandriens.jpg Research Labs - I. Langer - Jérôme JEANDRIENS MA in Biochemistry and Cellular and Molecular Biology (UMons, BE) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/493cc354-4d83-438e-a412-d318ae634b09/Romane+Meerts.jpg Research Labs - I. Langer - Romane MEERTS MA in Chemistry and Bio-Industries Bioengineering (ULB, BE) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/9a2c28f4-c790-416f-995e-b44e22e29c75/Negin+Asghariandehkordi.jpg Research Labs - I. Langer - Negin Asghariandehkordi BSc. In Biotechnology (University of Tehran, Iran) Student in Molecular and Medical Biotechnology at the University of Verona, Italy, and an Erasmus+ student in the MSc in Biomedical Science program at ULB https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/5421a6a2-dfee-4a4e-b996-7d92854829af/Nathalie+Tubez.jpg Research Labs - I. Langer - Nathalie TUBEZ MA in Biomedical Sciences, specialized in Translational medicine (ULB, BE) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/2685deaf-b316-4fee-9f48-658820131dbd/Viktorija+Vaitkeviciute+%281%29.jpg Research Labs - I. Langer - Viktorija VAITKEVIČIŪTĖ MA Sci. Pharmacology, University College London (UCL, UK) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/0b9fa09f-c496-4e58-b9b5-e85e3b981ffc/Image24.jpg Research Labs - I. Langer - Lilyan Suano BSc. In Medical Sciences (ULB) MSc student in Medical sciences at ULB. https://www.iribhm.org/research-labs/i-migeotte monthly 0.5 2026-03-02 https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/bedf3115-bf7d-4a43-9db0-7ddede8447f7/Diapositive1.png Research Labs - I. Migeotte The laboratory is devoted to the study of cell and cytoskeleton dynamics during early mammalian embryo development. We have two main themes of research: the mechanisms of gastrulation Epithelial-Mesenchymal Transition at the Primitive Streak after establishment of the anterior-posterior axis, and the subsequent morphogenesis of mesoderm-derived structures, in particular the extra-embryonic support membranes. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/3ea7fe10-e796-4c0b-8124-588adf584dac/Diapositive2-e1738669685410.png Research Labs - I. Migeotte - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/86b9d3e7-dfce-4802-9604-b94474a1e98b/Diapositive3-e1738669899119.png Research Labs - I. Migeotte - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/b2fb491c-8657-49f9-b387-0e3c74faa089/Diapositive4.png Research Labs - I. Migeotte - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/b2f1316c-0855-4ce5-9b38-72f98027399e/Frame+240.png Research Labs - I. Migeotte - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1738924211066-JVWMVU4LCS7GLGPPDL6S/image+28.png Research Labs - I. Migeotte https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1738924211061-KUAZ30HD2X3UCNEHRFIP/image+33.png Research Labs - I. Migeotte https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1738924211973-9H1S6GG0XDJXHI4OV3RB/image+35.png Research Labs - I. Migeotte https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/b4fc6d19-cec3-42a9-85b3-e15472535ebe/Isa-624x638.jpg Research Labs - I. Migeotte - Isabelle Migeotte Principal Investigator Research Associate F.N.R.S Email: isabelle.migeotte@ulb.be Phone: +32 (0)2 555 4529 I received a MD PhD from Université Libre de Bruxelles, and certified in Internal Medicine and Medical Genetics. I trained in Developmental Biology with Kathryn Anderson in Sloan-Kettering Institute in NYC. I became a FNRS Research Associate and Principal Investigator at IRIBHM in 2012. My laboratory focuses on the cellular mechanisms regulating morphogenesis of the mouse embryo and its extra-embryonic membranes. In parallel, I teach genetics to bachelor students in medicine and biomedical sciences and am a consultant at the ULB Centre of Human Genetics, with clinical (medical genetics consults) and research (diagnostic techniques/ gene discovery in clinical cohorts) interests. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/34ee8dd8-724b-4856-b480-b305026df9cb/Eliana+Nehme.jpg Research Labs - I. Migeotte - Eliana Nehme PhD Student I graduated from Notre Dame University-Lebanon (NDU) with a Bachelor of Science degree majoring in Medical Laboratory Technology. Afterwards, I was granted a scholarship that enabled me to complete my master’s degree in Biomedical Sciences: Biochemistry and Molecular Genetics at the American University of Beirut-Lebanon (AUB). My work focused on the epigenetic suppression of a group of evolutionary conserved transcription factors, the TBX2 subfamily, in human non-small cell lung cancer. Passionate about research, I joined Isabelle Migeotte’s lab in November 2022 thanks to the International PhD program of IRIBHM, and obtained a FRIA fellowship in 2023. My work focuses on the molecular determinants for the mechanical properties of the mouse embryo extra-embryonic membranes. Passionate about research, I joined Isabelle Migeotte’s lab in November 2022. My work focuses on the molecular determinants for the mechanical properties of the mouse embryo extra-embryonic membranes. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/77c19723-a65a-477c-9890-313a0178bdb4/Kristof.png Research Labs - I. Migeotte - Kristof Van Schoor PhD Student I obtained a professional bachelor’s degree in medical laboratory technology from the University of Applied Sciences and Art in Ghent in 2018. For my bachelor’s thesis, I studied the effects of decalcification on immunohistochemical staining in bone marrow diagnostics. In 2022, I received a master’s degree in biomedical sciences from the KU Leuven. I wrote my master thesis on canonical BMP signalling in the development of the intestinal lymphatic system with Prof. An Zwijsen at the Center for Molecular and Vascular Biology (KU Leuven). In November 2022, I joined the IRIBHM to study the development of the extraembryonic vasculature and the attachment of the umbilical cord to the placenta https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/c7bf5d72-354e-4d06-a305-85d7e70c2bcb/soryaCV-624x882.jpg Research Labs - I. Migeotte - Sorya Fagnoul PhD Student After completing my medical training (ULB) in 2016, I specialized in nephrology in 2022. I joined the Migeotte Lab in October 2022 with a grant from the Fonds Erasme. My project will endeavour to improve diagnosis of kidney diseases of genetical eatiology. In addition to monogenic diseases, I will explore more complex modes of inheritance, such as oligenic diseases, thanks to a novel method created by our colleagues at IB² (Interuniversity Institute of Bioinformatics in Brussels). In kidney transplantation, I will evaluate the value of a genetic diagnosis to reduce renal risk for both donor and recipient, but also maximise their matching to avoid organ rejection. Finally, I aim to establish a platform of renal organoids to test the variants of interest we will identify. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/d94cac69-cf00-449d-a0e5-5903179a7ff8/Emmanuel+Bruet+%281%29.jpg Research Labs - I. Migeotte - Emmanuel Bruet Post-doctoral fellow I obtained my bachelor’s degree in pharmacology from the Université d’Auvergne in Clermont-Ferrand, France in 2016. In 2019, I received a master’s degree in cellular signalization and neuroscience from the Université Paris-Saclay, France. During my master’s degree, I joined Doctor Sophie Creuzet’s Development and Evolution of the Neural Crest lab at the Paris-Saclay Institute of Neuroscience where I studied the emerging role of the cephalic neural crest-derived meninges and pericytes in cognitive impairment at birth. I pursued my research in the same laboratory with a PhD from 2019 to 2023 after receiving an IDEX grant from the French State. In December 2023, I joined Isabelle Migeotte’s lab to characterize the extra-embryonic vascular circulation through imaging and scRNAseq. https://www.iribhm.org/research-labs/ghopat-23kc9 monthly 0.5 2025-04-28 https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773217397-57DGRTOF1EP5BIEMCZJW/Image1.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773217180-2I43APEYN88F86FOXS13/Image2.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773218494-UH4VQDCIAE8VYCHQNV1N/Image3.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773218927-T9QP5SJ34PZZ6KQOZPE3/Image4.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773219982-FYT2S4D6RUTKENP3W4NV/Image5.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773220989-DZ2BR8K2JE01FMUOX6ZJ/Page+garde+1+-springael.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773222312-UXNG8657DWMWV9WAS284/Page+garde+2+springael.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/2cfefeda-50e3-4bb5-9772-47c5ef0108ba/isa-1.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology - Marie-Isabelle Garcia Lab Intestinal stem cell biology https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/8d05e5bd-ecba-411a-b60f-6e59befe44a1/ingrid-2.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology - Ingrid LANGER Lab Structure and function of VIP receptors in physiological and pathological conditions https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/b350cd65-0b0c-4851-a29a-8318676af7eb/jy-2.gif Research Labs - GHoPat - GPCRs in Homeostasis and Pathology - Jean-Yves SPRINGAEL Lab Chemokine Receptors in Physiology and Pathology https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/756f3ed4-fdfc-4c36-a5db-51ce3f02d42a/2025042247449978.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/f4d84347-48b4-47d4-901e-aa520561ac65/Marie-Isabelle+Garcia.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology - Marie-Isabelle Garcia, PhD PhD in Biochemistry (University Paris 7, FR) Professor of biochemistry at the Faculty of Medicine (ULB) Email : Marie.Garcia@ulb.be https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/669c3b65-78a1-4744-b851-3403e6f75287/Image15.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology - Ingrid Langer PharmD, PhD PhD in Pharmaceutical Sciences (ULB, BE) Professor of pharmacology at the Faculty of Medicine (ULB) Email : Ingrid.Langer@ulb.be https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/2e4f42ad-8271-40d4-9ce8-0d28008aa3dd/2025042246850714.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology - Jean-Yves Springael, PhD PhD in Chemical Sciences (ULB, BE) Professor of biochemistry at the Faculty of Medicine (ULB) Email : Jean-Yves.Springael@ulb.be https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/244b5895-2b84-4127-9089-7997f347998b/Morgane+Leprovots.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology - Morgane LEPROVOTS BA in Cellular biology, genetics, microbiology and physiology (University of Rennes -FR), vocational BA in biology (IUT Tours -FR) MA degree in life sciences and earth from the EPHE (FR) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/7f9f4d62-a5db-4a80-a253-d7a6ff18cf5c/Image18-1-2.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology - Giulia AGOSTINI MA in BIiomolecular, genomic and cellular Sciences (University of Parma, IT) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/87ac5284-8a45-412b-be36-aba499529446/original-4115DD5A-30BD-4CAB-B135-9D82CBF10159-624x907.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology - Lilian DEMOLIN, MD MD Medical sciences (ULB) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1ed8b055-8f91-4bb6-ba0a-300a32e7c5a8/J%C3%A9r%C3%B4me+Jeandriens.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology - Jérôme JEANDRIENS MA in Biochemistry and Cellular and Molecular Biology (UMons, BE) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/493cc354-4d83-438e-a412-d318ae634b09/Romane+Meerts.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology - Romane MEERTS MA in Chemistry and Bio-Industries Bioengineering (ULB, BE) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/9a2c28f4-c790-416f-995e-b44e22e29c75/Negin+Asghariandehkordi.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology - Negin Asghariandehkordi BSc. In Biotechnology (University of Tehran, Iran) Student in Molecular and Medical Biotechnology at the University of Verona, Italy, and an Erasmus+ student in the MSc in Biomedical Science program at ULB https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/5421a6a2-dfee-4a4e-b996-7d92854829af/Nathalie+Tubez.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology - Nathalie TUBEZ MA in Biomedical Sciences, specialized in Translational medicine (ULB, BE) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/2685deaf-b316-4fee-9f48-658820131dbd/Viktorija+Vaitkeviciute+%281%29.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology - Viktorija VAITKEVIČIŪTĖ MA Sci. Pharmacology, University College London (UCL, UK) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/0b9fa09f-c496-4e58-b9b5-e85e3b981ffc/Image24.jpg Research Labs - GHoPat - GPCRs in Homeostasis and Pathology - Lilyan Suano BSc. In Medical Sciences (ULB) MSc student in Medical sciences at ULB. https://www.iribhm.org/research-labs/isabelle-pirson monthly 0.5 2025-03-11 https://www.iribhm.org/research-labs/ghopat-23kc9-2a7k6 monthly 0.5 2026-02-06 https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773217397-57DGRTOF1EP5BIEMCZJW/Image1.jpg Research Labs - M.I Garcia https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773217180-2I43APEYN88F86FOXS13/Image2.jpg Research Labs - M.I Garcia https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773218494-UH4VQDCIAE8VYCHQNV1N/Image3.jpg Research Labs - M.I Garcia https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773218927-T9QP5SJ34PZZ6KQOZPE3/Image4.jpg Research Labs - M.I Garcia https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773219982-FYT2S4D6RUTKENP3W4NV/Image5.jpg Research Labs - M.I Garcia https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773220989-DZ2BR8K2JE01FMUOX6ZJ/Page+garde+1+-springael.jpg Research Labs - M.I Garcia https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773222312-UXNG8657DWMWV9WAS284/Page+garde+2+springael.jpg Research Labs - M.I Garcia https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/2cfefeda-50e3-4bb5-9772-47c5ef0108ba/isa-1.jpg Research Labs - M.I Garcia - Marie-Isabelle Garcia Lab Intestinal stem cell biology https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/8d05e5bd-ecba-411a-b60f-6e59befe44a1/ingrid-2.jpg Research Labs - M.I Garcia - Ingrid LANGER Lab Structure and function of VIP receptors in physiological and pathological conditions https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/b350cd65-0b0c-4851-a29a-8318676af7eb/jy-2.gif Research Labs - M.I Garcia - Jean-Yves SPRINGAEL Lab Chemokine Receptors in Physiology and Pathology https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/756f3ed4-fdfc-4c36-a5db-51ce3f02d42a/2025042247449978.jpg Research Labs - M.I Garcia - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/f4d84347-48b4-47d4-901e-aa520561ac65/Marie-Isabelle+Garcia.jpg Research Labs - M.I Garcia - Marie-Isabelle Garcia, PhD PhD in Biochemistry (University Paris 7, FR) Professor of biochemistry at the Faculty of Medicine (ULB) Email : Marie.Garcia@ulb.be https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/669c3b65-78a1-4744-b851-3403e6f75287/Image15.jpg Research Labs - M.I Garcia - Ingrid Langer PharmD, PhD PhD in Pharmaceutical Sciences (ULB, BE) Professor of pharmacology at the Faculty of Medicine (ULB) Email : Ingrid.Langer@ulb.be https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/2e4f42ad-8271-40d4-9ce8-0d28008aa3dd/2025042246850714.jpg Research Labs - M.I Garcia - Jean-Yves Springael, PhD PhD in Chemical Sciences (ULB, BE) Professor of biochemistry at the Faculty of Medicine (ULB) Email : Jean-Yves.Springael@ulb.be https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/244b5895-2b84-4127-9089-7997f347998b/Morgane+Leprovots.jpg Research Labs - M.I Garcia - Morgane LEPROVOTS BA in Cellular biology, genetics, microbiology and physiology (University of Rennes -FR), vocational BA in biology (IUT Tours -FR) MA degree in life sciences and earth from the EPHE (FR) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/7f9f4d62-a5db-4a80-a253-d7a6ff18cf5c/Image18-1-2.jpg Research Labs - M.I Garcia - Giulia AGOSTINI MA in BIiomolecular, genomic and cellular Sciences (University of Parma, IT) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/87ac5284-8a45-412b-be36-aba499529446/original-4115DD5A-30BD-4CAB-B135-9D82CBF10159-624x907.jpg Research Labs - M.I Garcia - Lilian DEMOLIN, MD MD Medical sciences (ULB) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1ed8b055-8f91-4bb6-ba0a-300a32e7c5a8/J%C3%A9r%C3%B4me+Jeandriens.jpg Research Labs - M.I Garcia - Jérôme JEANDRIENS MA in Biochemistry and Cellular and Molecular Biology (UMons, BE) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/493cc354-4d83-438e-a412-d318ae634b09/Romane+Meerts.jpg Research Labs - M.I Garcia - Romane MEERTS MA in Chemistry and Bio-Industries Bioengineering (ULB, BE) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/9a2c28f4-c790-416f-995e-b44e22e29c75/Negin+Asghariandehkordi.jpg Research Labs - M.I Garcia - Negin Asghariandehkordi BSc. In Biotechnology (University of Tehran, Iran) Student in Molecular and Medical Biotechnology at the University of Verona, Italy, and an Erasmus+ student in the MSc in Biomedical Science program at ULB https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/5421a6a2-dfee-4a4e-b996-7d92854829af/Nathalie+Tubez.jpg Research Labs - M.I Garcia - Nathalie TUBEZ MA in Biomedical Sciences, specialized in Translational medicine (ULB, BE) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/2685deaf-b316-4fee-9f48-658820131dbd/Viktorija+Vaitkeviciute+%281%29.jpg Research Labs - M.I Garcia - Viktorija VAITKEVIČIŪTĖ MA Sci. Pharmacology, University College London (UCL, UK) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/0b9fa09f-c496-4e58-b9b5-e85e3b981ffc/Image24.jpg Research Labs - M.I Garcia - Lilyan Suano BSc. In Medical Sciences (ULB) MSc student in Medical sciences at ULB. https://www.iribhm.org/research-labs/ghopat-23kc9-863eb monthly 0.5 2025-07-10 https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773217397-57DGRTOF1EP5BIEMCZJW/Image1.jpg Research Labs - JY Springael https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773217180-2I43APEYN88F86FOXS13/Image2.jpg Research Labs - JY Springael https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773218494-UH4VQDCIAE8VYCHQNV1N/Image3.jpg Research Labs - JY Springael https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773218927-T9QP5SJ34PZZ6KQOZPE3/Image4.jpg Research Labs - JY Springael https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773219982-FYT2S4D6RUTKENP3W4NV/Image5.jpg Research Labs - JY Springael https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773220989-DZ2BR8K2JE01FMUOX6ZJ/Page+garde+1+-springael.jpg Research Labs - JY Springael https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1743773222312-UXNG8657DWMWV9WAS284/Page+garde+2+springael.jpg Research Labs - JY Springael https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/2cfefeda-50e3-4bb5-9772-47c5ef0108ba/isa-1.jpg Research Labs - JY Springael - Marie-Isabelle Garcia Lab Intestinal stem cell biology https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/8d05e5bd-ecba-411a-b60f-6e59befe44a1/ingrid-2.jpg Research Labs - JY Springael - Ingrid LANGER Lab Structure and function of VIP receptors in physiological and pathological conditions https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/b350cd65-0b0c-4851-a29a-8318676af7eb/jy-2.gif Research Labs - JY Springael - Jean-Yves SPRINGAEL Lab Chemokine Receptors in Physiology and Pathology https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/756f3ed4-fdfc-4c36-a5db-51ce3f02d42a/2025042247449978.jpg Research Labs - JY Springael - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/f4d84347-48b4-47d4-901e-aa520561ac65/Marie-Isabelle+Garcia.jpg Research Labs - JY Springael - Marie-Isabelle Garcia, PhD PhD in Biochemistry (University Paris 7, FR) Professor of biochemistry at the Faculty of Medicine (ULB) Email : Marie.Garcia@ulb.be https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/669c3b65-78a1-4744-b851-3403e6f75287/Image15.jpg Research Labs - JY Springael - Ingrid Langer PharmD, PhD PhD in Pharmaceutical Sciences (ULB, BE) Professor of pharmacology at the Faculty of Medicine (ULB) Email : Ingrid.Langer@ulb.be https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/2e4f42ad-8271-40d4-9ce8-0d28008aa3dd/2025042246850714.jpg Research Labs - JY Springael - Jean-Yves Springael, PhD PhD in Chemical Sciences (ULB, BE) Professor of biochemistry at the Faculty of Medicine (ULB) Email : Jean-Yves.Springael@ulb.be https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/244b5895-2b84-4127-9089-7997f347998b/Morgane+Leprovots.jpg Research Labs - JY Springael - Morgane LEPROVOTS BA in Cellular biology, genetics, microbiology and physiology (University of Rennes -FR), vocational BA in biology (IUT Tours -FR) MA degree in life sciences and earth from the EPHE (FR) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/7f9f4d62-a5db-4a80-a253-d7a6ff18cf5c/Image18-1-2.jpg Research Labs - JY Springael - Giulia AGOSTINI MA in BIiomolecular, genomic and cellular Sciences (University of Parma, IT) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/87ac5284-8a45-412b-be36-aba499529446/original-4115DD5A-30BD-4CAB-B135-9D82CBF10159-624x907.jpg Research Labs - JY Springael - Lilian DEMOLIN, MD MD Medical sciences (ULB) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1ed8b055-8f91-4bb6-ba0a-300a32e7c5a8/J%C3%A9r%C3%B4me+Jeandriens.jpg Research Labs - JY Springael - Jérôme JEANDRIENS MA in Biochemistry and Cellular and Molecular Biology (UMons, BE) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/493cc354-4d83-438e-a412-d318ae634b09/Romane+Meerts.jpg Research Labs - JY Springael - Romane MEERTS MA in Chemistry and Bio-Industries Bioengineering (ULB, BE) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/9a2c28f4-c790-416f-995e-b44e22e29c75/Negin+Asghariandehkordi.jpg Research Labs - JY Springael - Negin Asghariandehkordi BSc. In Biotechnology (University of Tehran, Iran) Student in Molecular and Medical Biotechnology at the University of Verona, Italy, and an Erasmus+ student in the MSc in Biomedical Science program at ULB https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/5421a6a2-dfee-4a4e-b996-7d92854829af/Nathalie+Tubez.jpg Research Labs - JY Springael - Nathalie TUBEZ MA in Biomedical Sciences, specialized in Translational medicine (ULB, BE) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/2685deaf-b316-4fee-9f48-658820131dbd/Viktorija+Vaitkeviciute+%281%29.jpg Research Labs - JY Springael - Viktorija VAITKEVIČIŪTĖ MA Sci. Pharmacology, University College London (UCL, UK) https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/0b9fa09f-c496-4e58-b9b5-e85e3b981ffc/Image24.jpg Research Labs - JY Springael - Lilyan Suano BSc. In Medical Sciences (ULB) MSc student in Medical sciences at ULB. https://www.iribhm.org/research-labs/m-tarabichi monthly 0.5 2025-07-10 https://www.iribhm.org/research-labs/m-parmentier monthly 0.5 2026-02-06 https://www.iribhm.org/research-labs/blog-post-title-one-hp2ra monthly 0.5 2026-02-06 https://www.iribhm.org/research-labs/sumeet-pal-singh monthly 0.5 2025-07-10 https://www.iribhm.org/research-labs/v-wittamer monthly 0.5 2025-07-10 https://www.iribhm.org/research-labs/v-detours monthly 0.5 2025-07-10 https://www.iribhm.org/research-labs/x-bisteau monthly 0.5 2026-03-02 https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/0dc0564f-c329-4fa4-805e-cf609187282b/kinasetree--scaled.jpg Research Labs - X. Bisteau - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/33f538c4-7743-4de2-9a7d-709b540d1c77/chromosomes-defects-768x258.jpg Research Labs - X. Bisteau - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/f2560b8c-62e7-4608-b0d5-d51539bcc38c/20250627_Xav_Pic_Pro.jpg Research Labs - X. Bisteau - Xavier Bisteau, PhD Group leader (Xavier.Bisteau@ulb.ac.be) Dr Xavier Bisteau is an Assistant Professor of molecular and cell biology among the faculty of medicine at the Université Libre de Bruxelles (ULB) and a research group leader at the IRIBHM J.E. Dumont. He graduated as a molecular biologist (MS in 2007) and earned his PhD in biomedical and pharmaceutical sciences from the Université Libre de Bruxelles (ULB) in 2013. He performed a postdoctoral training at IMCB (A*STAR) in Singapore from 2013 to 2019. He was awarded major fundings (Marie Curie fellowship and Innoviris – Attract) to return as independent research fellow at ULB in 2019 and officially started his lab in 2021. His lab research focusses on the addiction of cancer to kinase activities, especially CDK4/6 and their responses to pharmacological inhibition, their interplay with microenvironment and the molecular mechanisms of intrinsic and acquired resistance. Besides his lab research, Pr. Bisteau is managing a growing core facility of Mass Spectrometry for proteomics analysis to assess protein abundances and post-translational modifications with numerous collaborators for various diseases as multiples sclerosis, Alzheimer, epilepsy both on experimental lab, patients’ samples as well as plants and other animals’ samples. Parallel to his teaching activities, Pr. Bisteau is pioneering pedagogical concepts, especially using numeric modules and systems including virtual reality as a tool for students to better learn and simulate environments and practical procedures. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/75ab1418-5323-49e6-ae00-fc6d82c3f921/Virginie+Imbault.jpg Research Labs - X. Bisteau - Virginie Imbault, MS Virginie received her master in genetics and microbiology in 2004 and a professional master in proteomics in 2005 from the University of Lille 1. She joined the institute in 2006 and is the technical manager of the proteomics facility. She is working in collaboration with our group, the group of David Communi and all collaborators interested in MS-based proteomics analyses. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/5dd7b8cc-d321-4108-aaf4-0eff4ab965b9/FabPhoto-300x300.jpg Research Labs - X. Bisteau - Fabiana Moresi, PhD student Fabiana Moresi is a Ph.D. candidate in Biomedical Science at the Université libre de Bruxelles (ULB), working in the laboratory of Prof. Xavier Bisteau. Her research investigates the heterogeneous and dynamic response of esophageal squamous cell carcinoma (eSCC) to CDK4/6 inhibition, using both 2D and 3D in vitro models. Fabiana earned her MSc with honors in Genetics and Molecular Biology from La Sapienza University of Rome and completed a double-degree program at the Magistère Européen de Génétique in Paris. Passionate about translational research and tumor modeling, she is currently collaborating with Dr. Andrea Pavesi at A*STAR, where she is exploring microfluidic-based platforms to recapitulate the tumor–immune microenvironment. Her work bridges molecular biology, cancer therapeutics, and bioengineering. Recipient of several awards—including the EMBO Scientific Exchange Grant and the FRIA doctoral fellowship—Fabiana actively mentors graduate students and contributes to international conferences. She is committed to advancing preclinical cancer models to better understand therapy resistance and immunomodulation. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/b0cbfd42-2ce2-49a5-b3c9-48e07ffa4acb/Marta-avalo-300x288.jpg Research Labs - X. Bisteau - Marta Avalo, PhD student Marta received her master degree in 2020 from the University of Granada. She further studied bioinformatics at the KU Leuven before joining the lab in November 2021. Marta is studying the dynamic changes of the protein-protein interaction network parallel to phosphorylation modulations following kinase inhibition in cancer. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/0ba0ba99-1718-40c0-aed4-68be7e556d38/Diego+Japon.jpg Research Labs - X. Bisteau - Diego Japón Ruiz, PhD Student … https://www.iribhm.org/research-labs/xde-deken monthly 0.5 2026-02-06 https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/2202af1e-8e51-4712-9726-5aded701558a/Image1-768x226.png Research Labs - X.De Deken - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1d243f94-74e2-4f54-8c74-f15432eb8d8f/Image2-768x269.png Research Labs - X.De Deken - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/096bb557-f598-4b27-b7eb-c30fc19fc0a6/Frame+239.png Research Labs - X.De Deken - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/d233246d-6936-47d9-bd20-660592c7a4d7/Fig1.jpg Research Labs - X.De Deken - The main function of the thyroid is the uptake and concentration of iodide via the Na+/I- symporteur (NIS) for thyroid hormone biosynthesis. Thyroid hormones, tri- and tetra-iodothyronine (T3 and T4), results from thyroperoxidase (TPO)-catalyzed iodination of thyroglobulin (TG) tyrosine residues and coupling of iodotyrosines. The thyroid hormones act on multiple organs in the body and influence critical physiological processes. Foremost, they are absolutely required for normal growth and neuronal maturation, preventing cretinism. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/ca8ff1a3-c989-4eb5-8585-864c70e634ff/Fig2-624x491.jpg Research Labs - X.De Deken - The thyroid gland generates massive amounts of H2O2 required for the biosynthesis of thyroid hormones. In 2000, we have discovered and characterized the molecular nature of the proteins responsible for this thyroid H2O2-generating system: the DUOX1 and DUOX2 enzymes. These proteins belong to a novel protein family, the NADPH-oxidases, presenting a catalytic domain involved in ROS generation. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1b597ec8-8e5b-432a-b195-f2d2abdbd681/Fig3-300x285.jpg Research Labs - X.De Deken - Our multidisciplinary projects aim to better characterize the function of these new oxidases and to study their physiological roles using human biological samples and transgenic animal models. Our research group tries to elucidate the mechanisms governing the processing and maturation of DUOX enzymes allowing their correct addressing at the cell surface. Moreover, using molecular approaches, the interactions between DUOX and their maturation factors DUOXA that influence the type of ROS generated (H2O2 or O2.-) are investigated. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/72b50d0b-9882-495e-a1cd-310f1ff72c8b/Fig5-624x469.jpg Research Labs - X.De Deken - The first genetic basis for transient CH has been proposed with the discovery of affected patients bearing mutations in DUOX2 gene. We identified the first inactivating DUOX2 mutation localized in the catalytic core of the oxidase. In collaboration with Pr. G Van Vliet (University of Montreal, Canada) and Pr. DP Carvalho (University of Rio de Janeiro, Brazil). https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/21f114dd-1c7e-4fa1-9a64-eda8b87a99ad/Fig8.jpg Research Labs - X.De Deken - The zebrafish thyroid is not organized in one compact gland encapsulated by connective tissue but consist of follicles of variable shape and diameter that lie individually between the first gill arch and the bulbus arteriosus along the ventral aorta. Compared to the two DUOX and two DUOXA genes present in mammals, only one duox and one single duoxa gene have been identified in the zebrafish genome. Expression of duox mRNA has been demonstrated in various extra-thyroid tissues including the brain, the epidermis, the intestine and the ultimobranchial bodies. In collaboration with the Costagliola Lab (Pr. S. Costagliola), we explored the role of duox and duoxa in thyroid function during zebrafish development using transgenic fish lines invalidated for the related genes. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/193ee6c0-09f7-4050-8a66-4bacc63a17c8/AITD-HE-768x266.png Research Labs - X.De Deken - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/430df555-08ec-40d4-abc3-003b5c4c74a7/AITD-IF.png Research Labs - X.De Deken - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1e7e1af7-7ffd-4c74-a6cd-d4240a3e65d8/Xavier+De+Deken.jpg Research Labs - X.De Deken - Xavier De Deken, PhD (xdedeken@ulb.ac.be) phone # +32 (0)2 555 4152 Xavier De Deken obtained a Master’s degree in Biomedical Sciences from ULB (1997). After his PhD
in Biomedical Sciences “Cloning and the characterization of the thyroid H2O2 generating system (2002 – ULB), Xavier performed a postdoctoral training at the IRCM, Montreal, Canada (2002 – 2004). Xavier joined back the laboratory in 2004 as a postdoctoral fellow. He obtained a permanent research position in the lab in 2010. His main research interests concern the biochemical characterization of the DUOX oxidases and their role in pathophysiological processes. https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/b6a21791-271d-4256-95ae-fafdf14d44ff/Image-150x150.jpeg Research Labs - X.De Deken - Zèna Shourbaji Zéna Shourbaji obtained her Master’s degree in Biomedical Sciences from ULB (2023). She started her PhD in Biomedical Sciences in 2023 at IRIBHM-ULB. The principal aim of her project is to better decipher the molecular events underlying the development of thyroid follicular cells (TFCs) via an unbiased approach using a pooled-library CRISPR/Cas9 screen on embryonic stem cell (ESC) derived thyroid organoids following the differentiation protocol developed by the laboratory of Pr. S. 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